The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
The role of cell‐penetrating peptides in potential anti‐cancer therapy
M Zhou, X Zou, K Cheng, S Zhong, Y Su… - Clinical and …, 2022 - Wiley Online Library
Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …
Platinum‐Coordinated Dual‐Responsive Nanogels for Universal Drug Delivery and Combination Cancer Therapy
Developing a universal nanoplatform for efficient delivery of various drugs to target sites is
urgent for overcoming various biological barriers and realizing combinational cancer …
urgent for overcoming various biological barriers and realizing combinational cancer …
Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins
JVV Arafiles, J Franke, L Franz… - Journal of the …, 2023 - ACS Publications
The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …
CASTING: a potent Supramolecular strategy to cytosolically deliver STING agonist for cancer immunotherapy and SARS-CoV-2 vaccination
JJ Wu, FY Chen, BB Han, HQ Zhang, L Zhao… - Ccs …, 2023 - chinesechemsoc.org
Stimulator of interferon genes, namely STING, an adaptor protein located in the endoplasmic
reticulum, has been recognized as a shining target for cancer and infection research …
reticulum, has been recognized as a shining target for cancer and infection research …
Cell-penetrating peptides for use in development of transgenic plants
Genetically modified plants and crops can contribute to remarkable increase in global food
supply, with improved yield and resistance to plant diseases or insect pests. The …
supply, with improved yield and resistance to plant diseases or insect pests. The …
First direct evidence for direct cell-membrane penetrations of polycationic homopoly (amino acid) s produced by bacteria
Y Takeuchi, K Ushimaru, K Kaneda… - Communications …, 2022 - nature.com
Bacteria produce polycationic homopoly (amino acid) s, which are characterized by
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …
Amplified Targeted Drug Delivery Independent of Target Number through Alternative Administration of Two Matched Nanoparticles
M Song, R Cao, X Chen, C Wang, X Xing, W Li, Y Li… - ACS …, 2023 - ACS Publications
Targeting nanoparticles (NPs) based on the specific binding of ligands with molecular
targets provides a promising tool for tissue-selective drug delivery. However, the number of …
targets provides a promising tool for tissue-selective drug delivery. However, the number of …
Cell-permeable peptide-based delivery vehicles useful for subcellular targeting and beyond
K Stillger, I Neundorf - Cellular Signalling, 2023 - Elsevier
Personal medicine aims to provide tailor-made diagnostics and treatments and has been
emerged as a promising but challenging strategy during the last years. This includes the …
emerged as a promising but challenging strategy during the last years. This includes the …
[HTML][HTML] Antibody–siRNA conjugates (ARC): Emerging siRNA drug formulation
W Cao, R Li, X Pei, M Chai, L Sun, Y Huang… - Medicine in Drug …, 2022 - Elsevier
Antibody–drug conjugates (ADC) utilizing the targeting properties of antibodies and
therapeutic effects of drugs have emerged a rapid development in recent years. However …
therapeutic effects of drugs have emerged a rapid development in recent years. However …