The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

The role of cell‐penetrating peptides in potential anti‐cancer therapy

M Zhou, X Zou, K Cheng, S Zhong, Y Su… - Clinical and …, 2022 - Wiley Online Library
Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

Platinum‐Coordinated Dual‐Responsive Nanogels for Universal Drug Delivery and Combination Cancer Therapy

QY Duan, YX Zhu, HR Jia, Y Guo, X Zhang, R Gu, C Li… - Small, 2022 - Wiley Online Library
Developing a universal nanoplatform for efficient delivery of various drugs to target sites is
urgent for overcoming various biological barriers and realizing combinational cancer …

Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins

JVV Arafiles, J Franke, L Franz… - Journal of the …, 2023 - ACS Publications
The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

CASTING: a potent Supramolecular strategy to cytosolically deliver STING agonist for cancer immunotherapy and SARS-CoV-2 vaccination

JJ Wu, FY Chen, BB Han, HQ Zhang, L Zhao… - Ccs …, 2023 - chinesechemsoc.org
Stimulator of interferon genes, namely STING, an adaptor protein located in the endoplasmic
reticulum, has been recognized as a shining target for cancer and infection research …

Cell-penetrating peptides for use in development of transgenic plants

BR Liu, CW Chen, YW Huang, HJ Lee - Molecules, 2023 - mdpi.com
Genetically modified plants and crops can contribute to remarkable increase in global food
supply, with improved yield and resistance to plant diseases or insect pests. The …

First direct evidence for direct cell-membrane penetrations of polycationic homopoly (amino acid) s produced by bacteria

Y Takeuchi, K Ushimaru, K Kaneda… - Communications …, 2022 - nature.com
Bacteria produce polycationic homopoly (amino acid) s, which are characterized by
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …

Amplified Targeted Drug Delivery Independent of Target Number through Alternative Administration of Two Matched Nanoparticles

M Song, R Cao, X Chen, C Wang, X Xing, W Li, Y Li… - ACS …, 2023 - ACS Publications
Targeting nanoparticles (NPs) based on the specific binding of ligands with molecular
targets provides a promising tool for tissue-selective drug delivery. However, the number of …

Cell-permeable peptide-based delivery vehicles useful for subcellular targeting and beyond

K Stillger, I Neundorf - Cellular Signalling, 2023 - Elsevier
Personal medicine aims to provide tailor-made diagnostics and treatments and has been
emerged as a promising but challenging strategy during the last years. This includes the …

[HTML][HTML] Antibody–siRNA conjugates (ARC): Emerging siRNA drug formulation

W Cao, R Li, X Pei, M Chai, L Sun, Y Huang… - Medicine in Drug …, 2022 - Elsevier
Antibody–drug conjugates (ADC) utilizing the targeting properties of antibodies and
therapeutic effects of drugs have emerged a rapid development in recent years. However …