Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …

Cells must sense and respond to sudden maladaptive environmental changes—stresses—
to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved …

In development, pioneer transcription factors access silent chromatin to reveal lineage-
specific gene programs. The structured DNA-binding domains of pioneer factors have been …

My accidental encounter with protein hydrogen exchange (HX) at its very beginning and its
continued development through my scientific career have led us to a series of advances in …

With the development of biomedical technology, epitope mapping of proteins has become
critical for developing and evaluating new protein drugs. The application of hydrogen …

The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein
complexes encompassing tumor neoantigens provide a rationale for target selection …

In this review, we detail the most common experimental approaches to assess and
characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR …

Hydrogen–deuterium exchange mass spectrometry (HDX-MS) is a powerful technique to
monitor protein intrinsic dynamics. The technique provides high-resolution information on …

Targeted degradation of proteins by chimeric heterobifunctional degraders has emerged as
a major drug discovery paradigm. Despite the increased interest in this approach, the criteria …