Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

Protein engineering has enormous academic and industrial potential. However, it is limited
by the lack of experimental assays that are consistent with the design goal and sufficiently …

To reduce experimental effort associated with directed protein evolution and to explore the
sequence space encoded by mutating multiple positions simultaneously, we incorporate …

Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with
intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials …

Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

The study of non-natural biocatalytic transformations relies heavily on empirical methods,
such as directed evolution, for identifying improved variants. Although exceptionally …

Biocatalysis is an effective tool to access chiral molecules that are otherwise hard to
synthesize or purify. Time-efficient processes are needed to develop enzymes that …

Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

Emerging computational tools promise to revolutionize protein engineering for biocatalytic
applications and accelerate the development timelines previously needed to optimize an …