Recent trends in biocatalysis
D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
The crucial role of methodology development in directed evolution of selective enzymes
Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
Low-N protein engineering with data-efficient deep learning
Protein engineering has enormous academic and industrial potential. However, it is limited
by the lack of experimental assays that are consistent with the design goal and sufficiently …
by the lack of experimental assays that are consistent with the design goal and sufficiently …
Machine learning-assisted directed protein evolution with combinatorial libraries
To reduce experimental effort associated with directed protein evolution and to explore the
sequence space encoded by mutating multiple positions simultaneously, we incorporate …
sequence space encoded by mutating multiple positions simultaneously, we incorporate …
Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes
Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with
intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials …
intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials …
The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …
This perspective is primarily aimed at synthetic organic chemists with limited experience …
Using Data Science for Mechanistic Insights and Selectivity Predictions in a Non-Natural Biocatalytic Reaction
HD Clements, AR Flynn, BT Nicholls… - Journal of the …, 2023 - ACS Publications
The study of non-natural biocatalytic transformations relies heavily on empirical methods,
such as directed evolution, for identifying improved variants. Although exceptionally …
such as directed evolution, for identifying improved variants. Although exceptionally …
Machine-directed evolution of an imine reductase for activity and stereoselectivity
Biocatalysis is an effective tool to access chiral molecules that are otherwise hard to
synthesize or purify. Time-efficient processes are needed to develop enzymes that …
synthesize or purify. Time-efficient processes are needed to develop enzymes that …
Enabling technology and core theory of synthetic biology
Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …
Accelerating biocatalysis discovery with machine learning: a paradigm shift in enzyme engineering, discovery, and design
B Markus, K Andreas, K Arkadij, L Stefan, O Gustav… - ACS …, 2023 - ACS Publications
Emerging computational tools promise to revolutionize protein engineering for biocatalytic
applications and accelerate the development timelines previously needed to optimize an …
applications and accelerate the development timelines previously needed to optimize an …