Long non-coding RNAs in the regulation of gene expression: physiology and disease
The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …
[HTML][HTML] B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
The long non-coding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in
female cells in early development and thereafter is thought to be largely dispensable. Here …
female cells in early development and thereafter is thought to be largely dispensable. Here …
The interplay of histone modifications–writers that read
T Zhang, S Cooper, N Brockdorff - EMBO reports, 2015 - embopress.org
Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
Long non-coding RNAs: new players in cell differentiation and development
A Fatica, I Bozzoni - Nature Reviews Genetics, 2014 - nature.com
Genomes of multicellular organisms are characterized by the pervasive expression of
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …
[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …
mammalian genomes and might play widespread roles in gene regulation and other cellular …
Xist RNA in action: Past, present, and future
A Loda, E Heard - PLoS genetics, 2019 - journals.plos.org
In mammals, dosage compensation of sex chromosomal genes between females (XX) and
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …
play an essential role in gene regulation, cellular differentiation, and development. However …
The implication of early chromatin changes in X chromosome inactivation
During development, the precise relationships between transcription and chromatin
modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm …
modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm …