In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …

Background With the ever increasing use of computational models in the biosciences, the
need to share models and reproduce the results of published studies efficiently and easily is …

Myokit is a new powerful and versatile software tool for modeling and simulation of cardiac
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a …

Across individuals within a population, several levels of variability are observed, from the
differential expression of ion channels at the molecular level, to the various action potential …

Concerns over cardiac side effects are the largest single cause of compound attrition during
pharmaceutical drug development. For a number of years, biophysically detailed …

Computational models of cardiac electrophysiology have a long history in basic science
applications and device design and evaluation, but have significant potential for clinical …

Introduction Unwanted drug interactions with ionic currents in the heart can lead to an
increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety …

Introduction Detection of drug-induced pro-arrhythmic risk is a primary concern for
pharmaceutical companies and regulators. Increased risk is linked to prolongation of the QT …