Isavuconazole: a new broad-spectrum triazole antifungal agent

MH Miceli, CA Kauffman - Clinical Infectious Diseases, 2015 - academic.oup.com
Isavuconazole is a new extended-spectrum triazole with activity against yeasts, molds, and
dimorphic fungi. It is approved for the treatment of invasive aspergillosis and mucormycosis …

Dermatophyte resistance to antifungal drugs: mechanisms and prospectus

NM Martinez-Rossi, TA Bitencourt, NTA Peres… - Frontiers in …, 2018 - frontiersin.org
Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized
structures present in nails, skin, and hair, causing superficial infections known as …

High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene

A Singh, A Masih, A Khurana, PK Singh, M Gupta… - Mycoses, 2018 - Wiley Online Library
In the last few years, infections caused by dermatophytes along with a concomitant increase
in the number of difficult to treat cases have increasingly been recognised, indicating that …

Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection

DML Saunte, RK Hare, KM Jørgensen… - Antimicrobial agents …, 2019 - Am Soc Microbiol
In recent years, cases involving terbinafine-resistant Trichophyton isolates have been
reported increasingly, particularly in India. We present 14 cases of terbinafine treatment …

State-of-the-art dermatophyte infections: epidemiology aspects, pathophysiology, and resistance mechanisms

NM Martinez-Rossi, NTA Peres, TA Bitencourt… - Journal of Fungi, 2021 - mdpi.com
The burden of fungal infections is not widely appreciated. Although these infections are
responsible for over one million deaths annually, it is estimated that one billion people are …

Molecular Epidemiology and Antifungal Susceptibility of Trichophyton Isolates in Greece: Emergence of Terbinafine-Resistant Trichophyton mentagrophytes Type …

M Siopi, I Efstathiou, K Theodoropoulos, S Pournaras… - Journal of Fungi, 2021 - mdpi.com
Trichophyton isolates with reduced susceptibility to antifungals are now increasingly
reported worldwide. We therefore studied the molecular epidemiology and the in vitro …

A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing …

A Singh, A Masih, J Monroy-Nieto, PK Singh… - Fungal Genetics and …, 2019 - Elsevier
There has been a considerable upsurge of extensive, treatment recalcitrant,
dermatophytosis presenting as tinea corporis and tinea cruris in India since the past few …

Multidrug‐resistant Trichophyton mentagrophytes genotype VIII in an Iranian family with generalized dermatophytosis: report of four cases and review of literature

A Fattahi, F Shirvani, A Ayatollahi… - International Journal …, 2021 - Wiley Online Library
Background The global spread of terbinafine‐resistant Trichophyton mentagrophytes with
point mutations in the squalene epoxidase (SQLE) gene is a big concern. Aim The present …

The Emerging Terbinafine-Resistant Trichophyton Epidemic: What Is the Role of Antifungal Susceptibility Testing?

JJ Shen, MC Arendrup, S Verma, DML Saunte - Dermatology, 2022 - karger.com
Background: Dermatophytosis is commonly encountered in the dermatological clinics. The
main aetiological agents in dermatophytosis of skin and nails in humans are Trichophyton …

Correlation of In Vitro Susceptibility Based on MICs and Squalene Epoxidase Mutations with Clinical Response to Terbinafine in Patients with Tinea Corporis/Cruris

A Khurana, A Masih, A Chowdhary… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Recalcitrant dermatophytoses are on the rise in India. High MICs of terbinafine (TRB) and
squalene epoxidase (SQLE) gene mutations conferring resistance in Trichophyton spp …