Hypertrophic scars and keloids can have significant detrimental effects on patients both
psychosocially and functionally. A careful identification of patient risk factors and a …

The tissue microenvironment regulates mammary gland development and tissue
homeostasis through soluble, insoluble and cellular cues that operate within the three …

Keloid and hypertrophic scars have affected patients and frustrated physicians for centuries.
Keloid and hypertrophic scars result from excessive collagen deposition, the cause of which …

The evidence base underpinning most traditional scar reduction approaches is limited, but
some of the novel strategies are promising and accumulating. We review a number of …

Tumor progression ensues within a three-dimensional microenvironment that consists of
cellular and non-cellular components. The extracellular matrix (ECM) and hypoxia are two …

The process of repair of wounded skin involves intricate orchestration not only between the
epidermal and dermal compartments but also between the resident and immigrant cells and …

Fig. 1.(A) HTS developed on a 34-year-old Caucasian man 8 months after a burn involving
60% of his TBSA.(B) Keloids on a 12-year-old black child following a scald burn including …

Significance: Hypertrophic scarring is a challenging issue for patients and clinicians. The
prevalence of hypertrophic scarring can be up to 70% after burns, and patients suffer from …

Hypertrophic scar and keloids are fibroproliferative disorders of the skin which occur often
unpredictably, following trauma and inflammation that compromise cosmesis and function …

Hypertrophic scars resulting from severe burns are usually treated by continuous elastic
compression. Although pressure therapy reaches success rates of 60–85% its mechanisms …