The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Advances in cancer immunotherapy have offered new hope for patients with metastatic
disease. This unfolding success story has been exemplified by a growing arsenal of novel …

Cell adhesion molecules (CAMs) are cell surface glycoproteins that facilitate cell-cell
contacts and adhesion with the extracellular matrix (ECM). Cellular adhesion is affected by …

Accumulating data indicates that following anti-cancer treatments, cancer cell death can be
perceived as immunogenic or tolerogenic by the immune system. The former is made …

Background Intravascular leukocyte recruitment in most vertebrate tissues is restricted to
postcapillary and collecting venules, whereas capillaries and arterioles usually support little …

The decrease of endothelial barrier function is central to the long-term inflammatory
response. A pathological alteration of the ability of endothelial cells to modulate the passage …

Background Data from large cardiac surgery registries have been depicting a downward
trend of mortality and morbidities in the last 20 years. However, despite decades of medical …

Mammalian platelets, devoid of nuclei, are the smallest cells in the blood stream. They are
essential for hemostasis, but also transmit cell signals that are necessary for regenerative …

The glycosciences aim to understand the impact of extracellular and intracellular
carbohydrate structures on biological function. These glycans primarily fall into three major …

Christensen AD, Haase C. Immunological mechanisms of contact hypersensitivity in mice.
APMIS 2012; 120: 1–27. Contact hypersensitivity (CHS) is an animal model in which the …