The tooth root is an integral, functionally important part of our dentition. The formation of a
functional root depends on epithelial-mesenchymal interactions and integration of the root …

The major mineralized tissues are bone and teeth, which share several mechanisms
governing their development and mineralization. This crossover includes the hormones that …

Abstract N6-methyladenosine (m6A) is the most abundant epigenetic modification in
eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian …

Cranial neural crest cells are an evolutionary innovation of vertebrates for craniofacial
development and function, yet the mechanisms that govern the cell fate decisions of …

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem
cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as …

The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have
preserved in evolution sufficient identities in their amino-terminal domains to share …

Dental follicle cells (DFCs) are a group of mesenchymal progenitor cells surrounding the
tooth germ, responsible for cementum, periodontal ligament, and alveolar bone formation in …

Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a
number of systemic hormones and transcription factors are known to regulate proliferation …

Formation of functional skeletal tissues requires highly organized steps of mesenchymal
progenitor cell differentiation. The dental follicle (DF) surrounding the developing tooth …