The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Ferroptosis is a newly described type of programmed cell death and intensively related to
both maintaining homeostasis and the development of diseases, especially cancers …

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known
as statins, are administered as first-line therapy for hypercholesterolemia, both as primary …

Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …

Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Lung cancer is the leading cause of cancer death in the world and there is no current
treatment able to efficiently treat the disease as the tumor is often diagnosed at an advanced …

Dysregulated metabolism is a common feature of cancer cells and is considered a hallmark
of cancer. Altered tumor-metabolism confers an adaptive advantage to cancer cells to fulfill …