The outcomes of Leishmania infection are determined by host immune and nutrition status,
parasite species, and co-infection with other pathogens. While subclinical infection and self …

In recent years, it has been an explosion of information regarding the role of various myeloid
cells in liver pathology. Macrophages and dendritic cell (DC) play crucial roles in multiple …

Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is
characterized by relentlessly increasing visceral parasite replication, cachexia, massive …

The Leishmania granuloma shares some, though not all, properties with that formed
following mycobacterial infection. As a simplified, noncaseating granuloma composed of …

Leishmania is a genus of protozoan parasites that give rise to a range of diseases called
Leishmaniasis that affects annually an estimated 1.3 million people from 88 countries …

Macrophages undergo swift changes in mRNA abundance upon pathogen invasion. Herein
we describe early remodelling of the macrophage transcriptome during infection by …

The RTS, S candidate malaria vaccine can protect against controlled human malaria
infection (CHMI), but how protection is achieved remains unclear. Here, we have analyzed …

Leishmania parasites are well adapted to initiate infection, resist the onslaught of innate
immunity and achieve a state of long‐lived persistence. In recent years, the tools available to …

Leishmaniasis is a tropical disease caused by Leishmania parasites and currently has no
licensed vaccines. We developed a dermotropic Leishmania major centrin gene-deleted …

Intracellular pathogens modulate host cell function to promote their survival. However, in
vitro infection studies do not account for the impact of host-derived inflammatory signals …