Background Physical frailty and sarcopenia show extensive clinical similarities. Whether
biomarkers exist that are shared by the two conditions is presently unclear. Methods We …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

Frailty and depression are important issues affecting older adults. Depressive syndrome
may be difficult to clinically disambiguate from frailty in advanced old age. Current reviews …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

Background The epigenetic clock, in particular epigenetic pre-aging quantified by the so-
called DNA methylation age acceleration, has recently been suggested to closely correlate …

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions
upstream of the disabling cascade. The lack of a unique operational definition for physical …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Even though they would have great benefit across research and clinical fields, currently
there are no accepted biomarkers of frailty. Cross-sectional studies in humans have …

Prolonged bed rest and lifelong physical inactivity cause deleterious effects to multiple
physiological systems that appear to hasten aging processes. Many such changes are …

Age‐related loss of skeletal muscle mass and strength are risk factors for sarcopenia,
osteoporosis, falls, fractures, frailty, and mortality. Dietary magnesium (Mg) could play a role …