Strategies for targeting gene therapy in cancer cells with tumor-specific promoters

M Montaño-Samaniego, DM Bravo-Estupiñan… - Frontiers in …, 2020 - frontiersin.org
Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases,
due to the lack of early diagnosis, and high relapse rate after conventional therapies …

[HTML][HTML] L-Norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer's disease

B Polis, KD Srikanth, E Elliott, H Gil-Henn, AO Samson - Neurotherapeutics, 2018 - Elsevier
The urea cycle is strongly implicated in the pathogenesis of Alzheimer's disease (AD).
Arginase-I (ARGI) accumulation at sites of amyloid-beta (Aβ) deposition is associated with L …

Advances in the computational and molecular understanding of the prostate cancer cell nucleus

NM Carleton, G Lee, A Madabhushi… - Journal of cellular …, 2018 - Wiley Online Library
Nuclear alterations are a hallmark of many types of cancers, including prostate cancer
(PCa). Recent evidence shows that subvisual changes, ones that may not be visually …

Bioinformatics and functional analyses of key genes in smoking‑associated lung adenocarcinoma

D Zhou, Y Sun, Y Jia, D Liu, J Wang… - Oncology …, 2019 - spandidos-publications.com
Smoking is one of the most important factors associated with the development of lung
cancer. However, the signaling pathways and driver genes in smoking‑associated lung …

High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer

M Gorbounov, NM Carleton, RJ Asch-Kendrick… - Breast cancer research …, 2020 - Springer
Purpose The high mobility group A1 (HMGA1) chromatin remodeling protein is required for
metastatic progression and cancer stem cell properties in preclinical breast cancer models …

miR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting UROC28 in hepatoma cells

Q Kong, J Han, H Deng, F Wu, S Guo… - OncoTargets and …, 2018 - Taylor & Francis
Objective MicroRNA (miR)-431 plays an essential role in various human cancer types,
particularly in the process of invasion. However, the function and mechanism of miR-431-5p …

Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genes

A Berglund, K Yamoah, SA Eschrich… - Cancer …, 2024 - Wiley Online Library
Abstract Introduction Men with African ancestry have the highest incidence and mortality
rates of prostate cancer (PCa) worldwide. Methods This study aimed to identify differentially …

Differential DNA methylation in prostate tumors from Puerto Rican men

G Ruiz-Deya, J Matta, J Encarnación-Medina… - International journal of …, 2021 - mdpi.com
In 2020, approximately 191,930 new prostate cancer (PCa) cases are estimated in the
United States (US). Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the …

Dysregulation of DNA methylation and epigenetic clocks in prostate cancer among puerto rican men

A Berglund, J Matta, J Encarnación-Medina… - Biomolecules, 2021 - mdpi.com
In 2021, approximately 248,530 new prostate cancer (PCa) cases are estimated in the
United States. Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US …

Towards Understanding the Key Signature Pathways Associated from Differentially Expressed Gene Analysis in an Indian Prostate Cancer Cohort

N Shukla, B Kour, D Sharma, M Vijayvargiya… - Diseases, 2023 - mdpi.com
Prostate cancer (PCa) is one of the most prevalent cancers among men in India. Although
studies on PCa have dealt with genetics, genomics, and the environmental influence in the …