Optimization of nanostructured lipid carriers: Understanding the types, designs, and parameters in the process of formulations
B Subramaniam, ZH Siddik, NH Nagoor - Journal of nanoparticle research, 2020 - Springer
Lipid-based nanoparticles for drug delivery have been employed in the development of
nanomedicine for various applications. One such versatile nanoparticle type is …
nanomedicine for various applications. One such versatile nanoparticle type is …
Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems
MT Luiz, JSR Viegas, JP Abriata, F Viegas… - European Journal of …, 2021 - Elsevier
Nanotechnology has been widely applied to develop drug delivery systems to improve
therapeutic performance. The effectiveness of these systems is intrinsically related to their …
therapeutic performance. The effectiveness of these systems is intrinsically related to their …
Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: formulation …
Rivastigmine is a drug commonly used in the management of Alzheimer's disease that
shows bioavailability problems. To overcome this, the use of nanosystems, such as …
shows bioavailability problems. To overcome this, the use of nanosystems, such as …
Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review
S Cunha, CP Costa, JN Moreira, JMS Lobo… - … , Biology and Medicine, 2020 - Elsevier
Abstract Quality-by-design (QbD) approach has been applied to optimize lipid-based
nanosystems formulations, including solid lipid nanoparticles (SLN), nanostructured lipid …
nanosystems formulations, including solid lipid nanoparticles (SLN), nanostructured lipid …
Boosting the brain delivery of Atazanavir through nanostructured lipid carrier-based approach for mitigating neuroaids
Atazanavir (ATZ) presents poor brain availability when administered orally, which poses a
major hurdle in its use as an effective therapy for the management of NeuroAIDS. The …
major hurdle in its use as an effective therapy for the management of NeuroAIDS. The …
Voriconazole loaded nanostructured lipid carriers based topical delivery system: QbD based designing, characterization, in-vitro and ex-vivo evaluation
T Waghule, VK Rapalli, G Singhvi, P Manchanda… - Journal of drug delivery …, 2019 - Elsevier
Clinical investigation showed that voriconazole exhibits various adverse effects such as
nausea, vomiting, and other gastric disturbances. To overcome these associated side …
nausea, vomiting, and other gastric disturbances. To overcome these associated side …
Statistically optimized tacrolimus and thymoquinone co-loaded nanostructured lipid carriers gel for improved topical treatment of psoriasis
The aim of this investigation was to develop and analyze a tacrolimus and thymoquinone co-
loaded nanostructured lipid carriers (TAC-THQ-NLCs)-based nanogel as a new …
loaded nanostructured lipid carriers (TAC-THQ-NLCs)-based nanogel as a new …
Development and optimization of imiquimod-loaded nanostructured lipid carriers using a hybrid design of experiments approach
Background Imiquimod (IMQ) is an immunomodulating drug that is approved for the
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …
Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: Full factorial design optimization, in vitro characterization, and pharmacokinetic …
A Zafar, OA Alsaidan, NK Alruwaili, SS Imam… - International Journal of …, 2022 - Elsevier
The objective of the present research was to develop, optimize, and evaluate rotigotine (RT)-
loaded chitosan (CH) coated nanostructured lipid carriers (RT-CH-NLCs) for nose-to-brain …
loaded chitosan (CH) coated nanostructured lipid carriers (RT-CH-NLCs) for nose-to-brain …
Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications …
The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid
nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and …
nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and …