Optimization of nanostructured lipid carriers: Understanding the types, designs, and parameters in the process of formulations

B Subramaniam, ZH Siddik, NH Nagoor - Journal of nanoparticle research, 2020 - Springer
Lipid-based nanoparticles for drug delivery have been employed in the development of
nanomedicine for various applications. One such versatile nanoparticle type is …

Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems

MT Luiz, JSR Viegas, JP Abriata, F Viegas… - European Journal of …, 2021 - Elsevier
Nanotechnology has been widely applied to develop drug delivery systems to improve
therapeutic performance. The effectiveness of these systems is intrinsically related to their …

Double optimization of rivastigmine-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach: formulation …

S Cunha, CP Costa, JA Loureiro, J Alves, AF Peixoto… - Pharmaceutics, 2020 - mdpi.com
Rivastigmine is a drug commonly used in the management of Alzheimer's disease that
shows bioavailability problems. To overcome this, the use of nanosystems, such as …

Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review

S Cunha, CP Costa, JN Moreira, JMS Lobo… - … , Biology and Medicine, 2020 - Elsevier
Abstract Quality-by-design (QbD) approach has been applied to optimize lipid-based
nanosystems formulations, including solid lipid nanoparticles (SLN), nanostructured lipid …

Boosting the brain delivery of Atazanavir through nanostructured lipid carrier-based approach for mitigating neuroaids

SA Khan, S Rehman, B Nabi, A Iqubal, N Nehal… - Pharmaceutics, 2020 - mdpi.com
Atazanavir (ATZ) presents poor brain availability when administered orally, which poses a
major hurdle in its use as an effective therapy for the management of NeuroAIDS. The …

Voriconazole loaded nanostructured lipid carriers based topical delivery system: QbD based designing, characterization, in-vitro and ex-vivo evaluation

T Waghule, VK Rapalli, G Singhvi, P Manchanda… - Journal of drug delivery …, 2019 - Elsevier
Clinical investigation showed that voriconazole exhibits various adverse effects such as
nausea, vomiting, and other gastric disturbances. To overcome these associated side …

Statistically optimized tacrolimus and thymoquinone co-loaded nanostructured lipid carriers gel for improved topical treatment of psoriasis

M Alam, M Rizwanullah, SR Mir, S Amin - Gels, 2023 - mdpi.com
The aim of this investigation was to develop and analyze a tacrolimus and thymoquinone co-
loaded nanostructured lipid carriers (TAC-THQ-NLCs)-based nanogel as a new …

Development and optimization of imiquimod-loaded nanostructured lipid carriers using a hybrid design of experiments approach

S Kim, S Abdella, F Abid, F Afinjuomo… - International Journal …, 2023 - Taylor & Francis
Background Imiquimod (IMQ) is an immunomodulating drug that is approved for the
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …

Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: Full factorial design optimization, in vitro characterization, and pharmacokinetic …

A Zafar, OA Alsaidan, NK Alruwaili, SS Imam… - International Journal of …, 2022 - Elsevier
The objective of the present research was to develop, optimize, and evaluate rotigotine (RT)-
loaded chitosan (CH) coated nanostructured lipid carriers (RT-CH-NLCs) for nose-to-brain …

Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications …

S Javed, B Mangla, Y Almoshari, MH Sultan… - Nanotechnology …, 2022 - degruyter.com
The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid
nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and …