Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …

Many diseases appear to be caused by the misregulation of protein maintenance. Such
diseases of protein homeostasis, or “proteostasis,” include loss-of-function diseases (cystic …

The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

Misfolded proteins associated with diverse aggregation disorders assemble not only into a
single toxic conformer but rather into a suite of aggregated conformers with unique …

Prions are proteins that access self-templating amyloid forms, which confer phenotypic
changes that can spread from individual to individual within or between species. These …

How small heat shock proteins (sHsps) might empower proteostasis networks to control
beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that …

In protein conformational disorders ranging from Alzheimer to Parkinson disease, proteins of
unrelated sequence misfold into a similar array of aggregated conformers ranging from …

Prion diseases are fatal, untreatable neurodegenerative diseases caused by the
accumulation of the misfolded, infectious isoform of the prion protein (PrP), termed PrPSc. In …