In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Mycotoxins are the most frequently occurring natural contaminants in human and animal
diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most …

Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and
feed, causing a variety of toxic effects in humans and animals. Currently, a series of …

Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Deoxynivalenol, also known as vomitotoxin, is produced by Fusarium, belonging to the
group B of the trichothecene family. DON is widely polluted, mainly polluting cereal crops …

Paradoxically, trichothecenes have both immunosuppressive and immunostimulatory
effects. The underlying mechanisms have not been fully explored. Early studies show that …

Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and,
therefore, must be highly regulated in order to avoid unnecessary energy expenditure. Not …

An increasing number of human beings from developed countries are colonized by
Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with …

Trichothecenes (TCT) are very common mycotoxins. While the effects of DON, the most
prevalent TCT, have been extensively studied, less is known about the effect of other …