Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

The discovery of N6-methyldeoxyadenine (6mA) across eukaryotes led to a search for
additional epigenetic mechanisms. However, some studies have highlighted confounding …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Various methyltransferases and demethylases catalyse methylation and demethylation of N
6-methyladenosine (m6A) and N 6, 2′-O-dimethyladenosine (m6Am) but precise …

Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology
representing intense therapeutic challenges. It is well known that deregulation of …

Maintenance of the mitochondrial genome is essential for proper cellular function. For this
purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed …

N 6-Methyladenine (6mA) is a naturally occurring DNA modification in both prokaryotes and
eukaryotes. Herein, we developed a deaminase-mediated sequencing (DM-seq) method for …

Abstract N 6-methyladenine (N 6-mA) of DNA is an emerging epigenetic mark in mammalian
genome. Levels of N 6-mA undergo drastic fluctuation during early embryogenesis …