Inflammatory bowel disease: pathophysiology and current therapeutic approaches

BP Abraham, T Ahmed, T Ali - Gastrointestinal pharmacology, 2017 - Springer
Inflammatory bowel diseases, most commonly categorized as Crohn's disease and
ulcerative colitis, are immune mediated chronic inflammatory disorders of the …

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement

P Nash, A Kerschbaumer, T Dörner… - Annals of the …, 2021 - ard.bmj.com
Objectives Janus kinase inhibitors (JAKi) have been approved for use in various immune-
mediated inflammatory diseases. With five agents licensed, it was timely to summarise the …

Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?

C Hasenoehrl, M Storr, R Schicho - Expert review of …, 2017 - Taylor & Francis
Introduction: Fifty years after the discovery of Δ9-tetrahydrocannabinol (THC) as the
psychoactive component of Cannabis, we are assessing the possibility of translating this …

Effectiveness and safety of vedolizumab in inflammatory bowel disease: a comprehensive meta-analysis of observational studies

FS Macaluso, M Ventimiglia… - Journal of Crohn's and …, 2023 - academic.oup.com
Abstract Background and Aims Many observational studies on the use of vedolizumab [VDZ]
in patients with Crohn's disease [CD] and ulcerative colitis [UC] have been published in the …

Compliance with the faecal calprotectin test in patients with inflammatory bowel disease

C Maréchal, I Aimone-Gastin… - United European …, 2017 - journals.sagepub.com
Background We investigated, for the first time, levels of compliance with faecal calprotectin
test in inflammatory bowel disease patients. Methods All consecutive adult inflammatory …

Effectiveness and safety of vedolizumab in biologically naïve patients: A real-world multi-centre study

FS Macaluso, W Fries, S Renna… - United European …, 2020 - journals.sagepub.com
Background Biologically naïve patients with inflammatory bowel disease treated with
vedolizumab (VDZ) are largely underrepresented in real-world cohorts. A multi-centre …

Anti-interleukin-12 and anti-interleukin-23 agents in Crohn's disease

FS Macaluso, A Orlando, M Cottone - Expert Opinion on Biological …, 2019 - Taylor & Francis
ABSTRACT Introduction: Blockers of IL-12/23, as well as specific blockers of IL-23, have
been investigated as options for medical therapy in inflammatory bowel disease. These …

Clinical benefit of vedolizumab on articular manifestations in patients with active spondyloarthritis associated with inflammatory bowel disease

A Orlando, R Orlando, F Ciccia, S Renna… - Annals of the …, 2017 - ard.bmj.com
Vedolizumab (VDZ) is a new biological agent which was recently approved for the treatment
of inflammatory bowel disease (IBD) 1 following the good clinical responses reported by …

[HTML][HTML] Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

X Zhang, L Song, L Li, B Zhu, L Huo, Z Hu… - … and Targeted Therapy, 2021 - nature.com
Inflammatory bowel disease (IBD) is a chronic and relapsing disorder for many people
associated with poor health. Although there are some clinical drugs for IBD treatment, the …

The real-world effectiveness of vedolizumab on intestinal and articular outcomes in inflammatory bowel diseases

FS Macaluso, R Orlando, W Fries, M Scolaro… - Digestive and Liver …, 2018 - Elsevier
Background The effectiveness of vedolizumab in real-world practice is under evaluation,
while its role in inflammatory bowel disease-associated spondyloarthritis is still unclear …