Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Sixteen flavonoids and related compounds have been tested for their ability to inhibit three
acidophilic Ser/Thr protein kinases: the Golgi apparatus casein kinase (G-CK) recently …

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases
are tightly regulated in the cell and play crucial regulatory roles in multiple cellular …

The term 'casein kinase'has been widely used for decades to denote protein kinases sharing
the ability to readily phosphorylate casein in vitro. These fall into three main classes: two of …

Introduction: The conventional term 'casein kinase'(CK) denotes three classes of kinases–
CK1, CK2 and Golgi-CK (G-CK)/Fam20C (family with sequence similarity 20, member C) …

We outline NMR protocols for site-specific mapping and time-resolved monitoring of protein
phosphorylation reactions using purified kinases and mammalian cell extracts. These …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …

Abstract Hypoxia-inducible factor-1 (HIF-1) is the key transcriptional mediator of the cellular
response to hypoxia and is also involved in cancer progression. Regulation of its oxygen …