Antidepressants are commonly prescribed medications in the United States, and there is
increasing interest in individualizing treatment selection for more than 20 US Food and Drug …

Membrane transporters play an essential role in the transport of endogenous and
exogenous compounds, and consequently they mediate the uptake, distribution, and …

Recently, a new class of extrachromosomal circular DNA, called microDNA, was identified.
They are on average 100 to 400 bp long and are derived from unique non-repetitive …

Methotrexate (MTX) is one of the staples of pediatric acute lymphoblastic leukemia (ALL)
treatment. MTX targets the folate metabolic pathway (FMP). Abnormal function of the …

Methotrexate (MTX), a structurally related substance to folic acid, is an important
chemotherapeutic agent used for decades in the treatment of pediatric acute lymphoblastic …

Methotrexate (MTX) is an important component in the therapy used to treat childhood acute
lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key …

Individualized treatment is of special importance in oncology because the drugs used for
chemotherapy have a very narrow therapeutic index. Pharmacogenetics may contribute …

Despite major advances in the management and high cure rates of childhood acute
lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities …

Vincristine (VCR), an important component of childhood acute lymphoblastic leukemia (ALL)
therapy, can cause sensory and motor neurotoxicity. This neurotoxicity could lead to dose …

Cancer is the leading cause of death in American children older than 1 year of age. Major
developments in drugs such as thiopurines and optimization in clinical trial protocols for …