Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, characterized by
the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

Alzheimer's disease (AD) is a severe age-dependent neurodegenerative disorder affecting
millions of people, with no cure so far. The current treatments only achieve some temporary …

In this research, we have implemented two-dimensional quantitative structure-activity
relationship (2D-QSAR) modeling using two different datasets, namely, acetylcholinesterase …

We have designed a series of tacrine-based homo-and heterodimers that incorporate an
antioxidant tether (selenoureido, chalcogenide) as new dual compounds: for the treatment of …

Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed
based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in …

Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

Pursuing the widespread interest on multi-target drugs to combat Alzheimer´ s disease (AD),
a new series of hybrids was designed and developed based on the repositioning of the well …