Until recently, inflammatory chemokines were viewed mainly as indispensable “gate
keepers” of immunity and inflammation. However, updated research indicates that cancer …

IL2 and IL15, members of the 4α-helix bundle family of cytokines, play pivotal roles in the
control of the life and death of lymphocytes. Although their heterotrimeric receptors have two …

Natural killer (NK) cells are important in innate immunity, first described as guardians for the
detection and clearance of transformed or virus‐infected cells. Later, this cell type was …

The microgravity environment experienced during spaceflight severely impaired immune
system, making astronauts vulnerable to various diseases that seriously threaten the health …

Abstract Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …

Abstract Interleukin-15 (IL-15) has recently emerged as a novel immunomodulatory cytokine
in cancer immunotherapy. IL-15 has the potential to reject and destroy cancer cells in the …

Microbial-triggered inflammation protects against pathogens and yet can paradoxically
cause considerable secondary damage to host tissues that can result in tissue fibrosis and …

Intravesical Bacillus Calmette-Guérin (BCG) has been shown to induce a specific
immunologic response (ie, activation of IL-2 and effector T-cells), while preclinical studies …

IL-15 is a 14–15 kDa member of the four α-helix bundle of cytokines that acts through a
heterotrimeric receptor involving IL-2/IL-15R β, γc and the IL-15 specific receptor subunit IL …

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose
tissue function. Although this view is supported by a large body of literature, it has been …