[HTML][HTML] Malaria genomics, vaccine development, and microbiome
Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …
[HTML][HTML] Gut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria
RK Mandal, A Mandal, JE Denny, R Namazii… - Nature …, 2023 - nature.com
Malaria is caused by Plasmodium species and remains a significant cause of morbidity and
mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of …
mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of …
[HTML][HTML] PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury
X Du, B Ren, C Li, Q Li, S Kan, X Wang, W Bai… - Nature …, 2024 - nature.com
Excessive host immune responses contribute to severe malaria with high mortality. Here, we
show that PRL2 in innate immune cells is highly related to experimental malaria disease …
show that PRL2 in innate immune cells is highly related to experimental malaria disease …
[HTML][HTML] Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis
ÂF Chora, S Marques, JL Gonçalves, P Lima… - Immunity, 2023 - cell.com
Plasmodium replicates within the liver prior to reaching the bloodstream and infecting red
blood cells. Because clinical manifestations of malaria only arise during the blood stage of …
blood cells. Because clinical manifestations of malaria only arise during the blood stage of …
A breath of fresh air: impact of insect-borne protozoan parasites on the respiratory system
S Araujo, D Mabille, AB Garcia, G Caljon - Trends in Parasitology, 2024 - cell.com
Abstract The protozoan parasites Plasmodium, Leishmania, and Trypanosoma are
transmitted by hematophagous insects and cause severe diseases in humans. These …
transmitted by hematophagous insects and cause severe diseases in humans. These …
[HTML][HTML] Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury
M Zhang, QR Wang, X Hou, Q Wang, X Yang, T Zhou… - Parasites & …, 2024 - Springer
Background Malaria-associated acute lung injury (MA-ALI) is a well-recognized clinical
complication of severe, complicated malaria that is partly driven by sequestrations of …
complication of severe, complicated malaria that is partly driven by sequestrations of …
Applicability of Redirecting Artemisinins for New Targets
J Golenser, NH Hunt, I Birman, CL Jaffe… - Global …, 2023 - Wiley Online Library
Employing new therapeutic indications for drugs that are already approved for human use
has obvious advantages, including reduced costs and timelines, because some routine …
has obvious advantages, including reduced costs and timelines, because some routine …
Evolutionary ecology of parasite strategies for within-host survival
AH Mainero - 2023 - era.ed.ac.uk
Plasmodium parasites, the causal agents of malaria, engage in complex interactions with
their hosts, however despite decades of research much of their life cycle remains …
their hosts, however despite decades of research much of their life cycle remains …