Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Natriuretic peptides are a family of three structurally related hormone/paracrine factors. Atrial
natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted from the cardiac …

The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum,
controls food transport, digestion, nutrient uptake, and hormone production. By single-cell …

Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal
pattern of skeletal growth plate vascularization and ossification. Although hypertrophic …

Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. It
possesses cytotoxic properties that are aimed against pathogenic microbes, but it can also …

Natriuretic peptides are a family of structurally related but genetically distinct
hormones/paracrine factors that regulate blood volume, blood pressure, ventricular …

Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

Although nitric oxide (NO) was identified more than 150 years ago and its effects were
clinically tested in the form of nitroglycerine, it was not until the decades of 1970–1990 that it …

Background & Aims Linaclotide is a minimally absorbed agonist of guanylate cyclase-C
(GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with …

Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-
undiscovered genetic factors. We carried out a meta-analysis of genome-wide association …