Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …

Tumor microenvironment is a special environment for tumor survival, which is characterized
by hypoxia, acidity, nutrient deficiency, and immunosuppression. The environment consists …

Highlights•Reviewed the function of arginine and its metabolites in arginine deprivation
therapy.•Discussed the difference of arginine deiminase and recombinant human arginase …

Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …

Cancer is the second leading cause of death globally. Chemotherapy and radiation therapy
and other medications are employed to treat various types of cancer. However, each …

Recently, there has been renewed interest in metabolic therapy for cancer, particularly in
amino acid deprivation by enzymes. L-asparaginase was approved for the treatment of …

Novel nanomaterials, including metallic nanoparticles obtained via green synthesis (gNPs),
have a great potential for application in biotechnology, industry and medicine. The special …

There are limited data on amperometric biosensors (ABSs) for L-arginine (Arg)
determination based on oxidases that produce hydrogen peroxide (H2O2) as a byproduct of …

There are limited data on amperometric biosensors (ABSs) based on deiminases that
produce ammonium as a byproduct of enzymatic reaction. The most frequently proposed …

Highlights•Liver cancer, a global threat, ranks sixth in incidence and is the second-leading
cause of cancer fatalities.•Despite effective treatments, issues like affordability and …