[HTML][HTML] MicroRNAs and cancer: Key paradigms in molecular therapy
W Tan, B Liu, S Qu, G Liang, W Luo… - Oncology …, 2018 - spandidos-publications.com
MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that performs an
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …
Regulation of breast cancer metastasis signaling by miRNAs
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
[HTML][HTML] Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor
microenvironment, although their origin and roles in shaping disease initiation, progression …
microenvironment, although their origin and roles in shaping disease initiation, progression …
[HTML][HTML] EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to
immunotherapy. Here, we show that KEAP1 targets EMSY for ubiquitin-mediated …
immunotherapy. Here, we show that KEAP1 targets EMSY for ubiquitin-mediated …
Intracellular entropy‐driven multi‐bit DNA computing for tumor progression discrimination
M Bai, F Chen, X Cao, Y Zhao, J Xue… - Angewandte Chemie …, 2020 - Wiley Online Library
Tumor progressions such as metastasis are complicated events that involve abnormal
expression of different miRNAs and enzymes. Monitoring these biomolecules in live cells …
expression of different miRNAs and enzymes. Monitoring these biomolecules in live cells …
[PDF][PDF] In vivo and in vitro impact of miR-31 and miR-143 on the suppression of metastasis and invasion in breast cancer
S Soheilyfar, Z Velashjerdi, YS Hajizadeh, NF Maroufi… - J buon, 2018 - researchgate.net
Summary Purpose: The microRNA (miR)-31 and miR-143 are pleiotropic anti-metastatic
miRs, with an expression that decreases significantly in metastatic breast cancer cells. The …
miRs, with an expression that decreases significantly in metastatic breast cancer cells. The …
[HTML][HTML] Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways
Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short
RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to …
RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to …
JARID1 histone demethylases: emerging targets in cancer
KM Harmeyer, ND Facompre, M Herlyn, D Basu - Trends in cancer, 2017 - cell.com
JARID1 proteins are histone demethylases that both regulate normal cell fates during
development and contribute to the epigenetic plasticity that underlies malignant …
development and contribute to the epigenetic plasticity that underlies malignant …
Function and regulation of microRNA‐31 in development and disease
NA Stepicheva, JL Song - Molecular reproduction and …, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are small noncoding RNAs that orchestrate numerous cellular
processes both under normal physiological conditions as well as in diseases. This review …
processes both under normal physiological conditions as well as in diseases. This review …
[HTML][HTML] Identification of CDC25 as a common therapeutic target for triple-negative breast cancer
CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1,
but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative …
but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative …