Respiratory, cardiovascular and musculoskeletal mechanisms involved in the pathophysiology of pulmonary hypertension: An updated systematic review of preclinical …

TC Freire, MS Ferreira, K De Angelis, M Paula-Ribeiro - Heart & Lung, 2024 - Elsevier
Background: Progressive exercise intolerance is a hallmark of pulmonary hypertension (pH),
severely impacting patients' independence and quality of life (QoL). Accumulating evidence …

MicroRNA-mRNA co-sequencing identifies transcriptional and post-transcriptional regulatory networks underlying muscle wasting in cancer cachexia

GJ Fernandez, JH Ferreira, IJ Vechetti Jr… - Frontiers in …, 2020 - frontiersin.org
Cancer cachexia is a metabolic syndrome with alterations in gene regulatory networks that
consequently lead to skeletal muscle wasting. Integrating microRNAs-mRNAs omics profiles …

Fractal analysis of right ventricular trabeculae in pulmonary hypertension

TJW Dawes, J Cai, M Quinlan, A de Marvao… - Radiology, 2018 - pubs.rsna.org
Purpose To measure right ventricular (RV) trabecular complexity by its fractal dimension
(FD) in healthy subjects and patients with pulmonary hypertension (PH) and to assess its …

Metformin prevents the development of monocrotaline‑induced pulmonary hypertension by decreasing serum levels of big endothelin‑1

T Yoshida, K Matsuura, S Goya… - Experimental and …, 2020 - spandidos-publications.com
Pulmonary hypertension (PH) is a disease with poor prognosis, and it is characterized by the
progressive elevation of pulmonary vascular resistance and pressure. Various factors are …

Fractal dimension analysis reveals skeletal muscle disorganization in mdx mice

SS Cury, PP Freire, B Martinucci, VC Dos Santos… - Biochemical and …, 2018 - Elsevier
Abstract Duchenne Muscular Dystrophy (DMD) is characterized by muscle extracellular
matrix disorganization due to the increased collagen deposition leading to fibrosis that …

Recovery of cardiac remodeling and dysmetabolism by pancreatic islet injury improvement in diabetic rats after yacon leaf extract treatment

KC Dos Santos, SS Cury, APCR Ferraz… - Oxidative Medicine …, 2018 - Wiley Online Library
Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and
its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats …

Combined physical training protects the left ventricle from structural and functional damages in experimental pulmonary arterial hypertension

LB Leite, LL Soares, AMO Portes, TI Soares… - Clinical …, 2024 - Springer
Background Under the adverse remodeling of the right ventricle and interventricular septum
in pulmonary arterial hypertension (PAH) the left ventricle (LV) dynamics is impaired …

Cardiovascular damage associated with subchronic exposure to the glyphosate herbicide in Wistar rats

FCC Maia, RA Porto, LR Magalhães… - Toxicology and …, 2021 - journals.sagepub.com
Glyphosate is the most widely used herbicide in the world. Although some studies have
shown cardiac electrophysiological changes associated to glyphosate, the histopathological …

Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity

CP Laurindo, KCR Gregorio, ACR Moreno… - Heliyon, 2021 - cell.com
Aim To investigate the effect of resistance training (RT) on hepatocardiovascular and muscle
mitochondrial parameters in rats that were fed a high-calorie diet for 12 weeks. Main …

Resistance training prevents right ventricle hypertrophy in rats exposed to secondhand cigarette smoke

ACR Moreno, GA Nai, CP Laurindo, KCR Gregorio… - Plos one, 2020 - journals.plos.org
Exposure to secondhand cigarette smoke is associated with the development of diverse
diseases. Resistance training has been considered one of the most useful tools for patients …