Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …

Roots are fundamentally important for growth and development, anchoring the plant to its
growth substrate, facilitating water and nutrient uptake from the soil, and sensing and …

In most organisms, the maturation of nascent RNAs is coupled to transcription. Unlike in
animals, the RNA polymerase II (RNAPII) transcribes microRNA genes (MIRNA s) as long …

R-loops are functional structures in chromatin comprising one single-stranded DNA and a
DNA: RNA hybrid. Here, we report ssDRIP-seq, a single-strand DNA ligation-based library …

R loops arising during transcription induce genomic instability, but how cells respond to the
R loop-associated genomic stress is still poorly understood. Here, we show that cells …

Genome topology is tied to R-loop formation and genome stability. However, the regulatory
mechanism remains to be elucidated. By establishing a system to sense the connections …

Using molecular dynamics simulations, we show here that growing plectonemes resulting
from transcription-induced supercoiling have the ability to actively push cohesin rings along …

Plant development is highly dependent on energy levels. TARGET OF RAPAMYCIN (TOR)
activates the proximal root meristem to promote root development in response to …

Chromatin-associated RNAs play key roles in various biological processes. However, both
their repository and conjugation genomic loci and potential functions remain largely unclear …

R-loops are a common chromatin feature with essential functions in multiple cellular
processes and diseases. However, little is known about the dynamic patterns of R-loops in a …