Ammonia borane as a reducing agent in organic synthesis
C Faverio, MF Boselli, F Medici… - Organic & Biomolecular …, 2020 - pubs.rsc.org
Ammonia borane NH3· BH3 is considered a promising material for hydrogen storage and
release, and is attracting increasing attention as a relatively inexpensive, atom economy …
release, and is attracting increasing attention as a relatively inexpensive, atom economy …
A growth selection system for the directed evolution of amine-forming or converting enzymes
Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …
synthesis of non-natural chiral chemicals, such as amines. However, most existing …
Ultrahigh-throughput screening enables efficient single-round oxidase remodelling
Biocatalysis provides a potentially sustainable means of chemical manufacturing. However,
the tailoring of enzymes to industrial processes is often laborious and time consuming …
the tailoring of enzymes to industrial processes is often laborious and time consuming …
Monoamine oxidase: tunable activity for amine resolution and functionalization
VF Batista, JL Galman, DC GA Pinto, AMS Silva… - ACS …, 2018 - ACS Publications
Monoamine oxidases (MAO) are biocatalysts for the oxidation of a wide range of different
amines including α-chiral amines. Their high selectivity and activity, along with the …
amines including α-chiral amines. Their high selectivity and activity, along with the …
Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N
A new directed evolution approach is presented to enhance the activity of an enzyme and to
manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) …
manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) …
Why leave a job half done? Recent progress in enzymatic deracemizations
A Díaz-Rodríguez, I Lavandera… - Current Green …, 2015 - ingentaconnect.com
In recent years the usefulness of enzymatic systems to obtain a single stereoisomerically
pure compound starting from a racemate has been expanded. Moreover, current advances …
pure compound starting from a racemate has been expanded. Moreover, current advances …
Combined imine reductase and amine oxidase catalyzed deracemization of nitrogen heterocycles
RS Heath, M Pontini, S Hussain, NJ Turner - ChemCatChem, 2016 - Wiley Online Library
A novel amine oxidase (AO)/imine reductase (IRED) system was developed for the
deracemization of racemic amines. By combining (R)‐6‐hydroxy‐d‐nicotine oxidase (6 …
deracemization of racemic amines. By combining (R)‐6‐hydroxy‐d‐nicotine oxidase (6 …
Tailoring D‐Amino Acid Oxidase from the Pig Kidney to R‐Stereoselective Amine Oxidase and its Use in the Deracemization of α‐Methylbenzylamine
K Yasukawa, S Nakano, Y Asano - … Chemie International Edition, 2014 - Wiley Online Library
The deracemization of racemic amines to yield enantioenriched amines using S‐
stereoselective amine oxidases (AOx) has recently been attracting attention. However, R …
stereoselective amine oxidases (AOx) has recently been attracting attention. However, R …
How to recruit a promiscuous enzyme to serve a new function
Promiscuous enzymes can be recruited to serve new functions when a genetic or
environmental change makes catalysis of a novel reaction important for fitness or even …
environmental change makes catalysis of a novel reaction important for fitness or even …
Synergistic chemo/biocatalytic synthesis of alkaloidal tetrahydroquinolines
The power of complementary chemocatalytic and biocatalytic transformations is
demonstrated in the asymmetric synthesis of 2-substituted tetrahydroquinolines. A series of …
demonstrated in the asymmetric synthesis of 2-substituted tetrahydroquinolines. A series of …