Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Cross-talk between the gut microbiota and the host immune system regulates host
metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut …

Interferons (IFNs) induce the expression of hundreds of genes as part of an elaborate
antimicrobial programme designed to combat infection in all nucleated cells—a process …

Toxoplasmosis is the clinical and pathological consequence of acute infection with the
obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from …

Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T.
gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell …

Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is
able to infect any warm-blooded vertebrate host. In addition to its importance to public …

The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Genome-wide association studies efficiently and powerfully assay common genetic
variation. The application of these studies to Crohn's disease has provided insight into the …

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs …