Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

After zidovudine (ZDV), a 3′-azido analogue of thymidine, was found to be an effective
antiretroviral drug against HIV [1, 2], other nucleoside analogues inhibiting reverse …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Background We describe severe and unexpected multisystem toxicity that occurred during a
study of the antiviral nucleoside analogue fialuridine (1-(2-deoxy-2-fluoro-β-d …

Cognitive disorders, vacuolar myelopathy, and sensory neuropathies associated with HIV
are the most common disorders in patients with HIV AIDS, and are the focus of this review …

OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …

Background Nucleoside analogues can induce toxic effects on mitochondria by inhibiting
the human DNA polymerase γ. The toxic effects can range from increased serum lactate …

Drug-associated dysfunction of mitochondria is believed to play a role in the etiology of the
various adverse symptoms that occur in human immunodeficiency virus (HIV)-infected …

To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of
nucleoside analogs used to treat AIDS, we examined the kinetics of incorporation catalyzed …

Drug-induced liver injury is an unresolved problem, with an impact well beyond the number
of actual cases that occur annually. It has emerged as the most frequent cause for …