Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials

JS Aday, BD Heifets, SD Pratscher, E Bradley… - …, 2022 - Springer
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

Post‐traumatic stress disorder: a state‐of‐the‐art review of evidence and challenges

RA Bryant - World psychiatry, 2019 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) is arguably the most common psychiatric disorder to
arise after exposure to a traumatic event. Since its formal introduction in the DSM‐III in 1980 …

[PDF][PDF] Psychedelics promote structural and functional neural plasticity

C Ly, AC Greb, LP Cameron, JM Wong, EV Barragan… - Cell reports, 2018 - cell.com
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of
depression and related disorders. The ability to promote both structural and functional …

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled …

MC Mithoefer, AA Feduccia, L Jerome, A Mithoefer… - …, 2019 - Springer
Background Posttraumatic stress disorder is a prevalent mental health condition with
substantial impact on daily functioning that lacks sufficient treatment options. Here we …

3, 4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a …

MC Mithoefer, AT Mithoefer, AA Feduccia… - The Lancet …, 2018 - thelancet.com
Background Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first
responders, many of whom do not respond to currently available treatments. This study …

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

NL Mason, KPC Kuypers, F Müller, J Reckweg… - …, 2020 - nature.com
There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin,
for disorders characterized by distortions of the self-experience, like depression …

Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials

L Jerome, AA Feduccia, JB Wang, S Hamilton… - …, 2020 - Springer
Rationale Posttraumatic stress disorder (PTSD) is a chronic condition that has wide-ranging
negative effects on an individual's health and interpersonal relationships. Treatments with …

A meta-analysis of placebo-controlled trials of psychedelic-assisted therapy

JB Luoma, C Chwyl, GJ Bathje, AK Davis… - Journal of …, 2020 - Taylor & Francis
After a two-decade hiatus in which research on psychedelics was essentially halted,
placebo-controlled clinical trials of psychedelic-assisted therapy for mental health conditions …

Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review

JJ Breeksema, BW Kuin, J Kamphuis… - Journal of …, 2022 - journals.sagepub.com
Introduction: Small-scale clinical studies with psychedelic drugs have shown promising
results for the treatment of several mental disorders. Before psychedelics become registered …

Psychedelic treatments for psychiatric disorders: A systematic review and thematic synthesis of patient experiences in qualitative studies

JJ Breeksema, AR Niemeijer, E Krediet, E Vermetten… - CNS drugs, 2020 - Springer
Introduction Interest in the use of psychedelic substances for the treatment of mental
disorders is increasing. Processes that may affect therapeutic change are not yet fully …