Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …
with a growing number of clinical studies examining a wide range of conditions and …
Post‐traumatic stress disorder: a state‐of‐the‐art review of evidence and challenges
RA Bryant - World psychiatry, 2019 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) is arguably the most common psychiatric disorder to
arise after exposure to a traumatic event. Since its formal introduction in the DSM‐III in 1980 …
arise after exposure to a traumatic event. Since its formal introduction in the DSM‐III in 1980 …
[PDF][PDF] Psychedelics promote structural and functional neural plasticity
C Ly, AC Greb, LP Cameron, JM Wong, EV Barragan… - Cell reports, 2018 - cell.com
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of
depression and related disorders. The ability to promote both structural and functional …
depression and related disorders. The ability to promote both structural and functional …
MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled …
MC Mithoefer, AA Feduccia, L Jerome, A Mithoefer… - …, 2019 - Springer
Background Posttraumatic stress disorder is a prevalent mental health condition with
substantial impact on daily functioning that lacks sufficient treatment options. Here we …
substantial impact on daily functioning that lacks sufficient treatment options. Here we …
3, 4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a …
MC Mithoefer, AT Mithoefer, AA Feduccia… - The Lancet …, 2018 - thelancet.com
Background Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first
responders, many of whom do not respond to currently available treatments. This study …
responders, many of whom do not respond to currently available treatments. This study …
Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin
There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin,
for disorders characterized by distortions of the self-experience, like depression …
for disorders characterized by distortions of the self-experience, like depression …
Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials
L Jerome, AA Feduccia, JB Wang, S Hamilton… - …, 2020 - Springer
Rationale Posttraumatic stress disorder (PTSD) is a chronic condition that has wide-ranging
negative effects on an individual's health and interpersonal relationships. Treatments with …
negative effects on an individual's health and interpersonal relationships. Treatments with …
A meta-analysis of placebo-controlled trials of psychedelic-assisted therapy
After a two-decade hiatus in which research on psychedelics was essentially halted,
placebo-controlled clinical trials of psychedelic-assisted therapy for mental health conditions …
placebo-controlled clinical trials of psychedelic-assisted therapy for mental health conditions …
Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review
JJ Breeksema, BW Kuin, J Kamphuis… - Journal of …, 2022 - journals.sagepub.com
Introduction: Small-scale clinical studies with psychedelic drugs have shown promising
results for the treatment of several mental disorders. Before psychedelics become registered …
results for the treatment of several mental disorders. Before psychedelics become registered …
Psychedelic treatments for psychiatric disorders: A systematic review and thematic synthesis of patient experiences in qualitative studies
Introduction Interest in the use of psychedelic substances for the treatment of mental
disorders is increasing. Processes that may affect therapeutic change are not yet fully …
disorders is increasing. Processes that may affect therapeutic change are not yet fully …