Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
Nonantibiotic prevention and management of recurrent urinary tract infection
N Sihra, A Goodman, R Zakri, A Sahai… - Nature Reviews …, 2018 - nature.com
Urinary tract infections (UTIs) are highly prevalent, lead to considerable patient morbidity,
incur large financial costs to health-care systems and are one of the most common reasons …
incur large financial costs to health-care systems and are one of the most common reasons …
Antibiotic adjuvants: a versatile approach to combat antibiotic resistance
The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …
Combination approaches to combat multidrug-resistant bacteria
RJ Worthington, C Melander - Trends in biotechnology, 2013 - cell.com
The increasing prevalence of infections caused by multidrug-resistant bacteria is a global
health problem that has been exacerbated by the dearth of novel classes of antibiotics …
health problem that has been exacerbated by the dearth of novel classes of antibiotics …
[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …
has limited efficacy against pulmonary TB disease development and modest protection …
Therapeutic strategies to combat antibiotic resistance
With multidrug resistant bacteria on the rise, new antibiotic approaches are required.
Although a number of new small molecule antibiotics are currently in the development …
Although a number of new small molecule antibiotics are currently in the development …
Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review
The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …
classes of antibiotics agents. The development of antibacterial agents with the novel method …
Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
A Lamut, L Peterlin Mašič, D Kikelj… - Medicinal Research …, 2019 - Wiley Online Library
Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
therapies to treat multidrug‐resistant pathogens has been recognized as an important …
Selective COX-2 inhibitors: road from success to controversy and the quest for repurposing
The introduction of selective COX-2 inhibitors (so-called 'coxibs') has demonstrated
tremendous commercial success due to their claimed lower potential of serious …
tremendous commercial success due to their claimed lower potential of serious …
Pharmaceutical approaches to target antibiotic resistance mechanisms
D Schillaci, V Spanò, B Parrino… - Journal of medicinal …, 2017 - ACS Publications
There is urgent need for new therapeutic strategies to fight the global threat of antibiotic
resistance. The focus of this Perspective is on chemical agents that target the most common …
resistance. The focus of this Perspective is on chemical agents that target the most common …