Three isozymes of nitric oxide (NO) synthase (EC 1.14. 13.39) have been identified and the
cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells) …

During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

Nitric oxide (NO) is synthesized by at least three distinct isoforms of NO synthase (NOS).
Their substrate and cofactor requirements are very similar. All three isoforms have some …

Nitric oxide is endogenously released in the airways by nitric oxide synthase. Functionally,
two isoforms of this enzyme exist: constitutive and inducible. The former seems to protect …

Even five years ago few could have realised that the simple gas nitric oxide (NO) would be
involved in the regulation of so many physiological functions and pathophysiological …

Nitric oxide (NO) is a highly reactive free radical with a multitude of organ specific regulatory
functions. Since 1985. NO has been the subject of numerous research efforts and as a …

In human airways, there is a prominent neural bronchodilator mechanism which is non-
adrenergic. In human tracheal segments, we have demonstrated that this response is …

Autonomic nerves in most mammalian species mediate both contractions and relaxations of
airway smooth muscle. Cholinergic-parasympathetic nerves mediate contractions, whereas …

The possibility that transmission at some non‐adrenergic, non‐cholinergic (NANC) neuro‐
effector junctions is mediated by nitric oxide (NO) arose from the discoveries that NO …

Nitric oxide is a pluripotential molecule that acts as both an autocrine and paracrine
mediator of homoeostasis, and derangement of its metabolism can be linked with many …