Two genes are synthetic lethal if mutation of either alone is compatible with viability but
mutation of both leads to death. So, targeting a gene that is synthetic lethal to a cancer …

Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …

Synthetic lethality occurs when the combination of two mutations leads to an inviable
organism. Screens for synthetic lethal genetic interactions have been used extensively to …

The nematode Caenorhabditis elegans was chosen as a model genetic organism because
its attributes, chiefly its hermaphroditic lifestyle and rapid generation time, make it suitable …

Proteins that are related to the retinoblastoma tumour suppressor pRB and the E2F
transcription factor are conserved in many species of plants and animals. The mammalian …

Since the discovery almost fifteen years ago that E2F transcription factors are key targets of
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …

New techniques have enhanced our picture of E2F regulation. These studies have shed
light on the roles played by individual E2F and retinoblastoma family members and implicate …

The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that,
together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C–Cdh1 …

Despite critical roles in development and cancer, the mechanisms that specify invasive
cellular behavior are poorly understood. Through a screen of transcription factors in …

A genetic interaction occurs when the combination of two mutations leads to an unexpected
phenotype. Screens for synthetic genetic interactions have been used extensively to identify …