Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the
adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical …

The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. Nrf2 induces the expression of detoxification and …

K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic
degradation of ubiquitinated targets, is up-regulated by various stressors. Induction of the …

The nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also called Nfe2l2) and its
cytoplasmic repressor, Kelch-like ECH-associated protein 1 (KEAP1), are major regulators …