Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis

N Sugimura, Q Li, ESH Chu, HCH Lau, W Fong, W Liu… - Gut, 2022 - gut.bmj.com
Objective Using faecal shotgun metagenomic sequencing, we identified the depletion of
Lactobacillus gallinarum in patients with colorectal cancer (CRC). We aimed to determine …

Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?

H Hou, D Chen, K Zhang, W Zhang, T Liu, S Wang… - Cancer Letters, 2022 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. It involves the complex interactions between genetic …

Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation

X Chen, R Wu, L Li, Y Zeng, J Chen, M Wei, Y Feng… - Immunity, 2023 - cell.com
The physiological and immune changes that occur during pregnancy are associated with
worsened disease outcomes during infection and sepsis. How these perturbations …

Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

Q Li, H Chan, WX Liu, CA Liu, Y Zhou, D Huang… - Cancer Cell, 2023 - cell.com
Carnobacterium maltaromaticum was found to be specifically depleted in female patients
with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor …

Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer

H Teng, Y Wang, X Sui, J Fan, S Li, X Lei, C Shi, W Sun… - Cancer Cell, 2023 - cell.com
Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …

Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB …

Y Zhang, L Zhang, S Zheng, M Li, C Xu, D Jia, Y Qi… - Gut …, 2022 - Taylor & Francis
Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the
spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and …

Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

L Zhao, X Zhang, Y Zhou, K Fu, HCH Lau, TWY Chun… - Oncogene, 2022 - nature.com
Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of
Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role and clinical …

Machine learning approaches in microbiome research: challenges and best practices

G Papoutsoglou, S Tarazona, MB Lopes… - Frontiers in …, 2023 - frontiersin.org
Microbiome data predictive analysis within a machine learning (ML) workflow presents
numerous domain-specific challenges involving preprocessing, feature selection, predictive …