Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …

Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a
(partial) activation of the epithelial–mesenchymal transition (EMT) programme. A …

Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …

Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …

Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA 1 s) are
considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA …

Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed
by caspase-3/7, which are dormant in living cells but become activated by upstream …

Glutathione peroxidase 4 (GPX4) is a promising target to induce ferroptosis for the treatment
of triple-negative breast cancer (TNBC). We designed and synthesized a novel series of …

Iron accumulation has been associated with the etiology and progression of multiple
neurodegenerative diseases (NDDs). The exact role of iron in these diseases is not fully …