Human genetic determinants of viral diseases

AD Kenney, JA Dowdle, L Bozzacco… - Annual review of …, 2017 - annualreviews.org
Much progress has been made in the identification of specific human gene variants that
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …

Tumour necrosis factor gene polymorphism and disease prevalence

T Qidwai, F Khan - Scandinavian journal of immunology, 2011 - Wiley Online Library
Tumour necrosis factor (TNF), an important proinflammatory cytokine, plays a role in the
regulation of cell differentiation, proliferation and death, as well as in inflammation, innate …

Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer

SS Wang, MC Bratti, AC Rodríguez… - The Journal of …, 2009 - academic.oup.com
Background. We examined host genetic factors to identify those more common in individuals
whose human papillomavirus (HPV) infections were most likely to persist and progress to …

Role of cytokines in genesis, progression and prognosis of cervical cancer

PH Paradkar, JV Joshi, PN Mertia… - Asian Pacific journal …, 2014 - koreascience.kr
Cytokine research is currently at the forefront in cancer research. Deciphering the functions
of these multiple small molecules, discovered within the cell and in intercellular spaces, with …

Association of HLA‐DRB1* 13 and TNF‐α gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population

P Kummee, P Tangkijvanich… - Journal of viral …, 2007 - Wiley Online Library
Considerable evidence suggests that host genetic factor play an important role in the
pathogenesis and clinical outcome of chronic hepatitis B virus (HBV) infection in several …

Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

A Pontillo, P Bricher, VNC Leal, S Lima… - Journal of medical …, 2016 - Wiley Online Library
Problem: Only a small proportion of HPV+ women develop virus‐associated lesions and
cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte …

TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk

G Barbisan, LO Pérez, A Contreras, CD Golijow - Tumor Biology, 2012 - Springer
Although the implication of genetic factors in cervical cancer development remains to be
elucidated, accumulative epidemiological evidence suggests that polymorphisms of cytokine …

Synergy between Cigarette Smoking and Human Papillomavirus Type 16 in Cervical Cancer In situ Development

AS Gunnell, TN Tran, A Torrång, PW Dickman… - … Biomarkers & Prevention, 2006 - AACR
Background: A majority of studies have implicated the involvement of cigarette smoking in
cervical cancer development, although its mechanism of action remains unclear. We …

Association of HLA‐DRB1, interleukin‐6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population—a candidate gene approach

FA Castro, K Haimila, I Sareneva… - … journal of cancer, 2009 - Wiley Online Library
High‐risk human papillomavirus (hrHPV) infection is the major risk factor for cervical cancer
(CxCa). The role of genetic susceptibility in the disease has been suggested, but the existing …

In vivo Role of Cytochrome P450 2E1 and Glutathione-S-Transferase Activity for Acrylamide Toxicokinetics in Humans

O Doroshyenko, U Fuhr, D Kunz, D Frank… - … Biomarkers & Prevention, 2009 - AACR
Acrylamide, a potential food carcinogen in humans, is biotransformed to the epoxide
glycidamide in vivo. Both acrylamide and glycidamide are conjugated with glutathione …