Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and tau aggregates in Alzheimer's disease

H Rai, S Gupta, S Kumar, J Yang… - Journal of Medicinal …, 2022 - ACS Publications
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …

[HTML][HTML] A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Discovery of high-affinity amyloid ligands using a ligand-based virtual screening pipeline

TS Chisholm, M Mackey, CA Hunter - Journal of the American …, 2023 - ACS Publications
Fibrillar protein aggregates are characteristic of neurodegenerative diseases but represent
difficult targets for ligand design, because limited structural information about the binding …

Near‐Infrared Bodipy‐Based Molecular Rotors for β‐Amyloid Imaging In Vivo

L Ma, Y Geng, G Zhang, Z Hu, TD James… - Advanced …, 2023 - Wiley Online Library
Abstract β‐amyloid (Aβ) is one of the important biomarkers for diagnosing Alzheimer's
disease (AD). Many near‐infrared probes based on the donor‐π‐acceptor structure have …

[HTML][HTML] Advances in development of fluorescent probes for detecting amyloid-β aggregates

M Xu, W Ren, X Tang, Y Hu, H Zhang - Acta Pharmacologica Sinica, 2016 - nature.com
With accumulating evidence suggesting that amyloid-β (Aβ) deposition is a good diagnostic
biomarker for Alzheimer's disease (AD), the discovery of active Aβ probes has become an …

Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer's disease

YI Gyasi, YP Pang, XR Li, JX Gu, XJ Cheng… - European Journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is characterized by progressive decrease in cognitive abilities,
language impairment and irreversible memory loss. Amyloid-β (Aβ) and tau deposits are …

Molecular tools to detect alloforms of Aβ and Tau: Implications for multiplexing and multimodal diagnosis of Alzheimer's disease

H Arora, M Ramesh, K Rajasekhar… - Bulletin of the …, 2020 - academic.oup.com
The advancements in the field of imaging and diagnostics have been benefitted by the
concurrent expansion of molecular probes space to monitor the diverse biological targets …

[HTML][HTML] White light emission from a simple mixture of fluorescent organic compounds

N Muhamad Sarih, P Myers, A Slater, B Slater… - Scientific Reports, 2019 - nature.com
Three fluorescent organic compounds—furocoumarin (FC), dansyl aniline (DA), and 7-
hydroxycoumarin-3-carboxylic acid (CC)—are mixed to produce almost pure white light …

Fluorescent imaging of β-amyloid using BODIPY based near-infrared off–on fluorescent probe

W Ren, J Zhang, C Peng, H Xiang, J Chen… - Bioconjugate …, 2018 - ACS Publications
Fluorescent imaging of β-amyloid (Aβ) is one of the most promising methods for Alzheimer's
disease diagnosis. Several fluorescent probes have been reported to detect Aβ both in vitro …

[HTML][HTML] BODIPY-based molecules for biomedical applications

S Das, S Dey, S Patra, A Bera, T Ghosh, B Prasad… - Biomolecules, 2023 - mdpi.com
BODIPY (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene) derivatives have attracted attention
as probes in applications like imaging and sensing due to their unique properties like (1) …