Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

The respiratory system, which consists of the lungs, trachea and associated vasculature, is
essential for terrestrial life. In recent years, extensive progress has been made in defining …

The functions of epithelial tissues are dictated by the types, abundance and distribution of
the differentiated cells they contain. Attempts to restore tissue function after damage require …

Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population.
However, the inter-patient and intra-tumor heterogeneity has not been addressed at single …

The upper airway epithelium, which is mainly composed of multiciliated, goblet, club and
basal cells, ensures proper mucociliary function and can regenerate in response to assaults …

The derivation of tissue-specific stem cells from human induced pluripotent stem cells
(iPSCs) would have broad reaching implications for regenerative medicine. Here, we report …

The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

Recent studies have revealed biologically significant differences between human and
mouse lung development, and have reported new in vitro systems that allow experimental …

In contrast to a prior emphasis on the finality of cell fate decisions in developmental systems,
cellular plasticity is now emerging as a general theme in the biology of multiple adult organ …

The vertebrate lung is elegantly patterned to carry out gas exchange and host defense.
Similar to other organ systems, endogenous stem and progenitor cells fuel the …