The morphology of cells is key to their function. Neurons extend a long axon and several
shorter dendrites to transmit signals in the nervous system. This process of neuronal …

The formation of complex nervous systems requires processes that coordinate proliferation,
migration and differentiation of neuronal cells. The remarkable morphological …

In differentiated axons almost all microtubules (MTs) uniformly point their plus ends towards
the axonal tip. The uniform polar pattern provides the structural substrate for efficient …

Transformation of a transected axonal tip into a growth cone (GC) is a critical step in the
cascade leading to neuronal regeneration. Critical to the regrowth is the supply and …

Background Dendrites differ from axons in patterns of growth and development, as well as in
morphology. Given that microtubules are key structural elements in cells, we assessed …

Through the use of live confocal imaging, electron microscopy, and the novel cell biological
platform of cultured Aplysia neurons we show that unfolding of the hallmark cell pathologies …

Axonal transport is a constitutive process that supplies the axon and axon terminal with
materials required to maintain their structure and function. Most materials are supplied via …

Differentiated mammalian cells are often characterized by highly specialized and polarized
structure. Its formation and maintenance depends on cytoskeletal components, among …

Following axotomy, both the proximal and distal cut axonal ends transform into growth cones
(GCs). Whereas the GCs formed by the tip of the proximal segment branch to form neurites …

Inhibition of microtubule dynamic instability prevents growth cone turning in response to
guidance cues, yet specific changes in microtubule polymerization as growth cones …