Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

Introduction: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2. 1.1), CA IX
and XII, involved in complex processes connected to tumorigenesis (pH regulation …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Hypoxia and acidosis are salient features of many tumors, leading to a completely different
metabolism compared to normal cells. Two of the simplest metabolic products, protons and …

Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce
bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases …

Sulfonamides revolutionized the treatment and management of bacterial infections. Prontosil
was the very first synthetic antibacterial agent ever used in the clinics and its metabolite …

Theranostics is the integration of diagnostic information with pharmaceuticals to increase
effectiveness and safety of cancer treatments. Nuclear medicine provides a non-invasive …

Unorthodox 18F-labeling strategies not employing the formation of a carbon-18F bond are
seldom found in radiochemistry. Historically, the formation of a boron-or silicon-18F bond …

Conspectus Positron emission tomography (PET) is revolutionizing our ability to visualize in
vivo targets for target validation and personalized medicine. Of several classes of imaging …

Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …