Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA
superhelicity and unlink double-stranded DNA segments during processes such as …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and
is essential for the separation of replicated sister chromatids and the integrity of cell division …

The spatial organization of the genome is enigmatic. Direct evidence of physical contacts
between chromosomes and their visualization at nanoscale resolution has been limited. We …

The centromere components cohesin, CENP-A, and centromeric DNA are essential for
biorientation of sister chromatids on the mitotic spindle and accurate sister chromatid …

During mitosis, sister chromatids must be faithfully segregated to ensure that daughter cells
receive one copy of each chromosome. However, following replication they often remain …

To perform double-stranded DNA passage, type II topoisomerases generate a covalent
enzyme-cleaved DNA complex (ie cleavage complex). Although this complex is a requisite …

Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation
by moving one double-stranded DNA segment through a transient break in a second duplex …

Type II topoisomerases are essential enzymes that modulate the topological state of DNA
supercoiling in all living organisms. These enzymes alter DNA topology by performing …

DNA topoisomerases pass DNA strands through each other, a function essential for all DNA
metabolic processes that create supercoils or entanglements of DNA. Topoisomerases play …