Glucocorticoids (GCs) are steroid hormones that exert important physiological actions on
metabolism. Given that GCs also exert potent immunosuppressive and anti-inflammatory …

Peripheral insulin resistance and pancreatic β‐cell dysfunction are hallmark characteristics
of type 2 diabetes mellitus (T2DM). Several contributing factors have been proposed to …

Introduction In this study we investigated the effects of high‐intensity resistance training (RT)
on dexamethasone (DEX)‐induced muscle atrophy in flexor hallucis longus (FHL), tibialis …

Aims: To explore the molecular mechanism by which 17β-estradiol (estrogen 2, E2)
regulates glucose transporter 2 (GLUT2) and insulin secretion in islet β cells through G …

Activation of insulin signaling and cell cycle intermediates is required for adult β-cell
proliferation. Here, we report a model to study β-cell proliferation in living rats by …

Multi-cellular systems require complex signaling mechanisms for proper tissue function, to
mediate signaling between cells in close proximity and at distances. This holds true for the …

In the present work, we developed, characterized, and tested an implantable graphene
bioscaffold which elutes dexamethasone (Dex) that can accommodate islets and adipose …

Long-term dexamethasone therapy may induce peripheral insulin resistance (IR), which in
turn elicits increased beta-cell function and proliferation. However, whether such adaptive …

This study investigated whether exercise training could prevent the negative side effects of
dexamethasone. Rats underwent a training period and were either submitted to a running …

Although glucocorticoids are widely used as antiinflammatory agents in clinical therapies,
they may cause serious side effects that include insulin resistance and hyperinsulinemia. To …