The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …

The myeloid neoplasms encompass acute myeloid leukemia, myelodysplastic syndromes
and myeloproliferative neoplasms. Most cases arise from the shared ancestor of clonal …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …

Clonal hematopoiesis of indeterminate potential (CHIP) is a prevalent age-related condition
wherein hematopoietic stem cells acquire a pathogenic mutation in a blood cancer driver …

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk
of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an …

Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …

Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms
underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential …

Individuals with clonal hematopoiesis of indeterminate potential (CHIP) are at increased risk
of aging related health conditions and all-cause mortality, but whether CHIP affects risk of …