Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

More than 20 years ago, Wood et al.(Curr Anthropol 33: 343–370, 1992) published “The
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …

Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …