Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of
ions and small molecules. Initially described as low-resistance ion pathways joining …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates diverse cellular
functions. It has been found that CD4+ CD25+ regulatory T (TREG) cells exert their …

Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors
in the mural granulosa cells of the ovarian follicle. Prior work has established the central role …

Evidence is accumulating that some forms of cell death, like apoptosis, are not only
governed by the complex interplay between extracellular and intracellular signals but are …

This review is based in part on a roundtable discussion session:“Physiological roles for
heterotypic/heteromeric channels” at the 2013 International Gap Junction Conference (IGJC …