Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the
inside of the nuclear membrane, where they provide a platform for the binding of proteins …

I discuss advances in the cell cycle in the 21 years since cyclin was discovered. The
surprising redundancy amongst the classical cyclins (A, B, and E) and cyclin-dependent …

CELL CYCLE CONTROL IN ANIMALS 443 established in many cases. Nonetheless, the
phosphorylation of nuclear lamins to promote nuclear disassembly (25, 31, 38-40), and the …

Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …

The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …