Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

[HTML][HTML] A comprehensive review of neuronal changes in diabetics

R Luna, RT Manjunatha, B Bollu, S Jhaveri… - Cureus, 2021 - ncbi.nlm.nih.gov
There has been an exponential rise in diabetes mellitus (DM) cases on a global scale.
Diabetes affects almost every system of the body, and the nervous system is no exception …

Therapeutic potential of polyphenols in the management of diabetic neuropathy

MT Kabir, N Tabassum, MS Uddin… - Evidence‐Based …, 2021 - Wiley Online Library
Diabetic neuropathy (DN) is a common and serious diabetes‐associated complication that
primarily takes place because of neuronal dysfunction in patients with diabetes. Use of …

[HTML][HTML] Drug repurposing–A search for novel therapy for the treatment of diabetic neuropathy

A Paul, M Kumar, P Das, N Guha, M Rudrapal… - Biomedicine & …, 2022 - Elsevier
Diabetic neuropathy is a chronic complication to metabolic disorder, diabetes mellitus. Till
date, diagnosis and treatment of diabetic neuropathy remain elusive with challenges …

[HTML][HTML] Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective

R Naseri, F Farzaei, S Fakhri, FF El-Senduny… - DARU Journal of …, 2019 - Springer
Objectives Diabetic neuropathy (DNP) is a widespread and debilitating complication with
complex pathophysiology that is caused by neuronal dysfunction in diabetic patients …

Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats

R Kosuru, S Singh - Life sciences, 2017 - Elsevier
Aims The present investigation was designed to explore the effectiveness of pterostilbene
(PT) on insulin resistance, metabolic syndrome and oxidative stress in fructose-fed insulin …

[HTML][HTML] Association between iron intake and diabetic peripheral neuropathy in type 2 diabetes: significance of iron intake and the ratio between iron intake and …

K Kim, YJ Song, TJ Oh, SH Choi, HC Jang - Nutrients, 2020 - mdpi.com
We aimed to investigate the association of iron and polyunsaturated fatty acid (PUFA) intake
with diabetic peripheral neuropathy (DPN) in individuals with type 2 diabetes. This cross …

Pramipexole protects against diabetic neuropathy: Effect on oxidative stress, TLR4/IRAK-1/TRAF-6/NF-κB and downstream inflammatory mediators

NH Eisa, SA Helmy, DH El-Kashef… - International …, 2024 - Elsevier
Background Diabetic neuropathy (DN) is a serious microvascular complication and a major
cause of morbidity and mortality in diabetes mellitus. It is characterized by …

[HTML][HTML] Evaluation of photobiomodulation and boldine as alternative treatment options in two diabetic retinopathy models

V Calbiague García, B Cadiz, P Herrera, A Díaz… - International Journal of …, 2023 - mdpi.com
Diabetic retinopathy causes progressive and irreversible damage to the retina through
activation of inflammatory processes, overproduction of oxidative species, and glial …

[HTML][HTML] The role of gut microflora and the cholinergic anti-inflammatory neuroendocrine system in diabetes mellitus

PJ Parekh, VR Nayi, DA Johnson… - Frontiers in Endocrinology, 2016 - frontiersin.org
The obesity epidemic has drastically impacted the state of health care in the United States.
Paralleling this epidemic is the incidence of diabetes mellitus, with a notable shift toward a …